Gastroenterology
Maddrey's Discriminant Function & Lille Model (Alcoholic Hepatitis)
Calculates Maddrey Discriminant Function (mDF ≥ 32) to determine steroid eligibility in severe alcohol-associated hepatitis.
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Parameters
Maddrey's Discriminant Function & Lille Model (Alcoholic Hepatitis) Result
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Formula
mDF = 4.6 × [Patient PT (sec) - Control PT (sec)] + Total Bilirubin (mg/dL)
mDF ≥ 32 defines severe alcoholic hepatitis with ~35–50% 30-day mortality.Clinical Pearls
Pivotal clinical decision rule that identifies patients with life-threatening alcoholic hepatitis who derive clear survival benefit from corticosteroid therapy.
Limitations
Laboratory PT variation between reagents requires using exact control PT from the same testing laboratory.