Pharmacology

Clinical Pharmacokinetics Loading Dose & Maintenance Infusion Calculator

Calculates Loading Dose (LD), Maintenance Dose (MD), continuous infusion rate, and steady-state kinetics.

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Parameters

Clinical Pharmacokinetics Loading Dose & Maintenance Infusion Calculator Result

Formula

Loading Dose (mg) = (Ctarget × Vd_total) / F
Maintenance Dose (mg) = (Css × Clearance × τ) / F
Continuous Infusion (mg/hr) = Css × Clearance

Clinical Pearls

Allows immediate attainment of therapeutic plasma drug levels in severe sepsis or critical arrhythmias without waiting 4–5 elimination half-lives.

Limitations

Assumes linear first-order one-compartment kinetics. Does not apply to capacity-limited / non-linear Michaelis-Menten elimination (e.g., phenytoin, ethanol).