Endocrinology
HOMA-B
Estimates pancreatic beta-cell function from fasting glucose and insulin.
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Parameters
HOMA-B Result
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Formula
HOMA-B (%) = (360 × Fasting Insulin [µU/mL]) / (Fasting Glucose [mg/dL] - 63)
(Note: If glucose is in mmol/L, formula is (20 × Insulin) / (Glucose - 3.5))Clinical Pearls
Helps distinguish whether hyperglycemia is primarily driven by insulin resistance (high HOMA-IR) or beta-cell failure (low HOMA-B).
Limitations
Not valid if fasting glucose is ≤ 63 mg/dL. Not validated for use in patients receiving exogenous insulin therapy. Less accurate in severe hyperglycemia (glucose toxicity).