Nephrology
Furosemide Stress Test (FST for AKI Progression)
Evaluates 2-hour urinary response to loop diuretic challenge to predict progression to severe Stage 3 AKI and RRT.
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Parameters
Furosemide Stress Test (FST for AKI Progression) Result
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Formula
FST Challenge: 1.0 mg/kg IV (diuretic naive) or 1.5 mg/kg IV (prior loop diuretic use).
Cutoff: 2-hour cumulative urine output < 200 mL indicates severe AKI progression risk (AUC-ROC 0.87).Clinical Pearls
Provides a reliable functional dynamic assessment of renal reserve, identifying critically ill patients who will fail conservative management and require early dialytic intervention.
Limitations
Contraindicated in anuria, pre-existing Stage 5 CKD (baseline eGFR < 15), renal allograft, or acute volume depletion.