Nephrology

Cockcroft-Gault Creatinine Clearance

Estimates creatinine clearance (CrCl) for renal drug dosing adjustments.

Parameters

years

Cockcroft-Gault Creatinine Clearance Result

--
FormulaCrCl (mL/min) = [ (140 - Age) × Weight (kg) ] / [ 72 × Serum Creatinine (mg/dL) ] × (0.85 if Female)

Clinical Pearls

Mandated by regulatory bodies (FDA, EMA) for pharmacokinetic studies and medication package insert labeling for renal dose adjustments.

Limitations

Can overestimate clearance in obese patients (where Adjusted Body Weight should be considered) and in cachectic patients with low muscle mass.